AVN-322 free base

CAS No. 1194574-33-8

AVN-322 free base ( AVN 323 free base )

Catalog No. M10683 CAS No. 1194574-33-8

A highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    AVN-322 free base
  • Note
    Research use only, not for human use.
  • Brief Description
    A highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia.
  • Description
    A highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia; significantly restores both scopolamine- and MK-801-induced cognitive dysfunction and demonstrates antipsychotic potential.Alzheimer Disease Phase 2 Clinical
  • Synonyms
    AVN 323 free base
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    Neurological Disease
  • Indication
    Alzheimer Disease

Chemical Information

  • CAS Number
    1194574-33-8
  • Formula Weight
    357.43
  • Molecular Formula
    C17H19N5O2S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CNC1=NN2C3=C(CN(CC3)C)C=NC2=C1S(=O)(=O)C4=CC=CC=C4
  • Chemical Name
    N,7-dimethyl-3-(phenylsulfonyl)-6,7,8,9-tetrahydropyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-2-amine hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ivachtchenko AV, et al. Curr Alzheimer Res. 2017;14(3):268-294.
molnova catalog
related products
  • CTEP

    CTEP (RO4956371) is a novel, long-acting, orally bioavailable allosteric antagonist of mGlu5 receptor with IC50 of 2.2 nM, shows >1000-fold selectivity over other mGlu receptors.

  • Ziprasidone

    A full antagonist of D2 and 5-HT2A receptors with Ki of 6.8 and 0.6 nM, respectively; also is a partial agonist of 5-HT1A, and a partial antagonist of 5-HT2C and 5-HT1D receptors.

  • Chlorprothixene

    Chlorprothixene is a typical antipsychotic drug of the thioxanthene class and was the first of the series to be synthesized.